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Functional Connectivity of Corticostriatal Circuitry and Psychosis-like Experiences in the General Community

  • Kristina Sabaroedin
    Correspondence
    Address correspondence to Kristina Sabaroedin, GradDip(Hons), Brain and Mental Health Research Hub, 770 Blackburn Road, Clayton, Victoria 3168, Australia.
    Affiliations
    Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia

    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia
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  • Jeggan Tiego
    Affiliations
    Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia

    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia
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  • Linden Parkes
    Affiliations
    Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia

    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia
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  • Francesco Sforazzini
    Affiliations
    Monash Biomedical Imaging, Monash University, Victoria, Australia
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  • Amy Finlay
    Affiliations
    Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia

    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia
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  • Beth Johnson
    Affiliations
    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia
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  • Ari Pinar
    Affiliations
    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia
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  • Vanessa Cropley
    Affiliations
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
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  • Ben J. Harrison
    Affiliations
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
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  • Andrew Zalesky
    Affiliations
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
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  • Christos Pantelis
    Affiliations
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia
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  • Mark Bellgrove
    Affiliations
    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia
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  • Alex Fornito
    Affiliations
    Brain and Mental Health Research Hub, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia

    School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Victoria, Australia

    Monash Biomedical Imaging, Monash University, Victoria, Australia
    Search for articles by this author
Published:February 21, 2019DOI:https://doi.org/10.1016/j.biopsych.2019.02.013

      Abstract

      Background

      Psychotic symptoms are proposed to lie on a continuum, ranging from isolated psychosis-like experiences (PLEs) in nonclinical populations to frank disorder. Here, we investigated the neurobiological correlates of this continuum by examining whether functional connectivity of dorsal corticostriatal circuitry, which is disrupted in psychosis patients and individuals at high risk for psychosis, is associated with the severity of subclinical PLEs.

      Methods

      A community sample of 672 adults with no history of psychiatric or neurological illnesses completed a battery of seven questionnaires spanning various PLE domains. Principal component analysis of 12 subscales taken from seven questionnaires was used to estimate major dimensions of PLEs. Dimension scores from principal component analysis were then correlated with whole-brain voxelwise functional connectivity maps of the dorsal striatum in a subset of 353 participants who completed a resting-state neuroimaging protocol.

      Results

      Principal component analysis identified two dimensions of PLEs that accounted for 62.57% of variance in the measures, corresponding to positive (i.e., subthreshold delusions and hallucinations) and negative (i.e., subthreshold social and physical anhedonia) symptom-like PLEs. Reduced functional connectivity between the dorsal striatum and prefrontal and motor cortices correlated with more severe positive PLEs. Increased functional connectivity between the dorsal striatum and motor cortex was associated with more severe negative PLEs.

      Conclusions

      Consistent with past findings in patients and individuals at high risk for psychosis, subthreshold positive symptomatology is associated with reduced functional connectivity of the dorsal circuit. This finding suggests that the connectivity of this circuit tracks the expression of psychotic phenomena across a broad spectrum of severity, extending from the subclinical domain to clinical diagnosis.

      Keywords

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