From Stress Sensitization to Microglial Priming and Vice Versa: A New Era of Research in Biological Psychiatry

  • Robert Dantzer
    Address correspondence to Robert Dantzer, D.V.M, Ph.D., The University of Texas MD Anderson Cancer Center, Department of Symptom Research, 1515 Holcombe Dr, Houston, TX 77030
    Department of Symptom Research, Unit 1450, The University of Texas MD Anderson Cancer Center, Houston, Texas
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      Linked Article

      • The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat
        Biological PsychiatryVol. 85Issue 8
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          Stress is associated with an increased prevalence of anxiety and depression. Repeated social defeat (RSD) stress in mice increases the release of monocytes from the bone marrow that are recruited to the brain by microglia. These monocytes enhance inflammatory signaling and augment anxiety. Moreover, RSD promotes stress sensitization, in which exposure to acute stress 24 days after cessation of RSD causes anxiety recurrence. The purpose of this study was to determine whether microglia were critical to stress sensitization and exhibited increased reactivity to subsequent acute stress or immune challenge.
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