Histone Crotonylation Makes Its Mark in Depression Research

  • Jennifer C Chan
    Department of Neuroscience, Friedman Brain Institute, New York, New York
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  • Ian Maze
    Address correspondence to Ian Maze, Ph.D., Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Pl, New York, NY 10029.
    Department of Neuroscience, Friedman Brain Institute, New York, New York

    Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
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      Linked Article

      • Chromodomain Y-like Protein–Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors
        Biological PsychiatryVol. 85Issue 8
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          Major depressive disorder is a prevalent and life-threatening illness in modern society. The susceptibility to major depressive disorder is profoundly influenced by environmental factors, such as stressful lifestyle or traumatic events, which could impose maladaptive transcriptional program through epigenetic regulation. However, the underlying molecular mechanisms remain elusive. Here, we examined the role of histone crotonylation, a novel type of histone modification, and chromodomain Y-like protein (CDYL), a crotonyl-coenzyme A hydratase and histone methyllysine reader, in this process.
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