Parsing the Hippocampus in Depression: Chronic Stress, Hippocampal Volume, and Major Depressive Disorder

  • Yvette I. Sheline
    Address correspondence to Yvette I. Sheline, M.D., Center for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania, 3700 Hamilton Walk, Richards D307, Philadelphia, PA 19104.
    Center for Neuromodulation in Depression and Stress, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania
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  • Conor Liston
    Departments of Psychiatry and Neuroscience, Weill Cornell Medical College, the Rockefeller University, New York, New York
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  • Bruce S. McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, the Rockefeller University, New York, New York
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      Linked Article

      • The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology
        Biological PsychiatryVol. 85Issue 6
        • Preview
          Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among the most well-documented neural abnormalities in major depressive disorder (MDD). Hippocampal and mPFC structural reductions have been specifically tied to MDD illness progression markers, including greater number of major depressive episodes (MDEs), longer illness duration, and nonremission/treatment resistance. Chronic stress plays a critical role in the development of hippocampal and mPFC deficits, with some studies suggesting that these deficits occur irrespective of MDE occurrence.
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      • The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression
        Biological PsychiatryVol. 85Issue 6
        • Preview
          Hippocampal volume reduction is the most replicated finding in neuroimaging studies of major depressive disorder (MDD). Varying hippocampal volume definition is a well-established problem in this field. Given that hippocampal function can be mapped onto anatomically defined substructures and that detailed examination of substructure volumes is now possible, we examined different hippocampal composite measures in MDD to look for hippocampal markers of MDD.
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