Commentary| Volume 84, ISSUE 12, P862-864, December 15, 2018

Deconstructing and Reconstructing the Dichotomy That Is Dopamine Receptor-1– and Dopamine Receptor-2–Expressing Neurons

  • Peter W. Kalivas
    Address correspondence to Peter W. Kalivas, Ph.D., Department of Neuroscience, Medical University of South Carolina, 173 Ashley Ave, BSB403, Charleston, SC 29425.
    Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina
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      Linked Article

      • Cocaine-Induced Structural Plasticity in Input Regions to Distinct Cell Types in Nucleus Accumbens
        Biological PsychiatryVol. 84Issue 12
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          The nucleus accumbens (NAc) is a brain region implicated in pathological motivated behaviors such as drug addiction and is composed predominantly of two discrete populations of neurons, dopamine receptor-1– and dopamine receptor-2–expressing medium spiny neurons (D1-MSNs and D2-MSNs, respectively). It is unclear whether these populations receive inputs from different brain areas and whether input regions to these cell types undergo distinct structural adaptations in response to the administration of addictive drugs such as cocaine.
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