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Accepted: September 12, 2018
Received: September 12, 2018
© 2018 Society of Biological Psychiatry.
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- Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain’s Reward CircuitryBiological PsychiatryVol. 84Issue 12
- PreviewGlobal changes in gene expression underlying circuit and behavioral dysregulation associated with cocaine addiction remain incompletely understood. Here, we show how a history of cocaine self-administration (SA) reprograms transcriptome-wide responses throughout the brain’s reward circuitry at baseline and in response to context and/or cocaine re-exposure after prolonged withdrawal (WD).