Novel In Vivo Investigation of the Brain Nociceptin/Orphanin FQ System in Alcohol Use Disorder: Are There Lessons From a Negative Neuroimaging Study?

  • Laura M. Best
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

    Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
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  • Isabelle Boileau
    Address correspondence to Isabelle Boileau, Ph.D., Centre for Addiction and Mental Health, Addiction Imaging Research Group, Head, 250 College St (PET Centre), Toronto, Ontario, M5T 1R8, Canada.
    Campbell Family Mental Health Research Institute and Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

    Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

    Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
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      Linked Article

      • Nociceptin Receptors in Alcohol Use Disorders: A Positron Emission Tomography Study Using [11C]NOP-1A
        Biological PsychiatryVol. 84Issue 10
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          The neuropeptide transmitter nociceptin, which binds to the nociceptin/orphanin FQ peptide (NOP) receptor, is a core component of the brain's antistress system. Nociceptin exerts its antistress effect by counteracting the functions of corticotropin-releasing factor, the primary stress-mediating neuropeptide in the brain. Basic investigations support a role for medications that target nociceptin receptors in the treatment of alcohol use disorders. Thus, it is of high interest to measure the in vivo status of NOP receptors in individuals with alcohol use disorders.
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