The Importance of Drug and Sex Effects in Psychiatric Research

  • Ansel T. Hillmer
    Address correspondence to Ansel T. Hillmer, Ph.D., Yale University School of Medicine, 2 Church St. South, #314, New Haven, CT 06520.
    Departments of Psychiatry and Radiology and Biomedical Imaging and the Yale Positron Emission Tomography Center, Yale University School of Medicine, New Haven, Connecticut
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      Linked Article

      • Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography
        Biological PsychiatryVol. 84Issue 10
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          Previous studies showed reduction of brain cannabinoid CB1 receptors in adults with cannabis and alcohol use disorders. Preclinical data suggest that these receptors also contribute to nicotine reward and dependence. Tobacco smoking may confound clinical studies of psychiatric disorders because many patients with such disorders smoke tobacco. Whether human subjects who smoke tobacco but are otherwise healthy have altered CB1 receptor binding in brain is unknown.
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