Through the early 1950s, nearly 20,000 children were born each year with congenital
heart defects. The majority of these “blue babies” would die almost immediately. The
pioneering surgeon C. Walton Lillehei performed the first successful repair of a ventral
septal defect. But even after this miraculous intervention, Lillehei’s patients were
not in the clear. The team discovered that after surgery, the children’s hearts could
still unpredictably stop beating if there was damage to the vulnerable electrical
conduction system. A solution existed, but it was far from ideal. Cardiologist Paul
Zoll had recently developed a large pacemaker machine that could deliver periodic
electrical impulses through electrodes strapped to the chest. Though it saved lives,
the treatment was painful, and the child’s mobility was limited to the length of the
electrical cord.
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References
- A brief history of cardiac pacing.Tex Heart Inst J. 1993; 20: 12-18
- Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT): A Consortium for Research in ECT (CORE) report.J Clin Psychiatry. 2004; 65: 485-491
- Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: Implications for clinical practice.Am J Psychiatry. 2006; 163: 28-40
- Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: A multisite randomized controlled trial.Biol Psychiatry. 2007; 62: 1208-1216
- Deep brain stimulation for treatment-resistant depression.Neuron. 2005; 45: 651-660
- A randomized sham-controlled trial of deep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression.Biol Psychiatry. 2015; 78: 240-248
- Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial.Epilepsia. 2014; 55: 432-441
- Adaptive deep brain stimulation in advanced Parkinson disease.Ann Neurol. 2013; 74: 449-457
- Resting-state quantitative electroencephalography reveals increased neurophysiologic connectivity in depression.PLoS One. 2012; 7: e32508
- The antidepressant treatment response index and treatment outcomes in a placebo-controlled trial of fluoxetine.J Clin Neurophysiol. 2011; 28: 478-482
Article info
Publication history
Accepted:
August 13,
2018
Received in revised form:
August 10,
2018
Received:
August 8,
2018
Identification
Copyright
© 2018 Society of Biological Psychiatry.