Deep brain stimulation (DBS) is investigated as a possible therapy for treatment-resistant
depression (TRD) (
1
,
2
,
3
,
4
,
5
,
6
,
7
). DBS of the superolateral medial forebrain bundle (slMFB) is associated with rapid
and sustained antidepressant effects (
8
). Little is known about the effect of DBS cessation after long-term treatment in psychiatric
disorders. Previous clinical studies showed aggravation of depression after DBS discontinuation
in TRD. Prediscontinuation level could be recaptured following different timelines
after reinitiation of stimulation (
2
,
9
,
10
).To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression.Biol Psychiatry. 2008; 64: 461-467
- Deep brain stimulation for treatment-resistant depression.Neuron. 2005; 45: 651-660
- Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression.Biol Psychiatry. 2010; 67: 110-116
- Deep brain stimulation for treatment-resistant depression: Follow-up after 3 to 6 years.Am J Psychiatry. 2011; 168: 502-510
- Rapid effects of deep brain stimulation for treatment-resistant major depression.Biol Psychiatry. 2013; 73: 1204-1212
- Deep brain stimulation of the subcallosal cingulate gyrus: Further evidence in treatment-resistant major depression.Int J Neuropsychopharmacol. 2012; 15: 121-133
- Long-term effects of nucleus accumbens deep brain stimulation in treatment-resistant depression: Evidence for sustained efficacy.Neuropsychopharmacology. 2012; 37: 1975-1985
- Deep brain stimulation to the medial forebrain bundle for depression-long-term outcomes and a novel data analysis strategy.Brain Stimul. 2017; 10: 664-671
- Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression.Arch Gen Psychiatry. 2012; 69: 150-158
- Deep brain stimulation of the ventral anterior limb of the internal capsule for treatment-resistant depression: A randomized clinical trial.JAMA Psychiatry. 2016; 73: 456-464
- Camino de Santiago.(Available at:)http://santiago-compostela.net/(Accessed September 3, 2018)Date: 2018
- A new depression scale designed to be sensitive to change.Br J Psychiatry. 1979; 134: 382-389
- A rating scale for depression.J Neurol Neurosurg Psychiatry. 1960; 23: 56-62
- Acute antidepressant effects of deep brain stimulation—Review and data from slMFB-stimulation.Pers Med Psychiatr. 2017; 3: 1-7
- Beck Depressions-Inventar (BDI-II).Harcourt Test Services, Frankfurt, Germany2006
- A brief mental health outcome scale-reliability and validity of the Global Assessment of Functioning (GAF).Br J Psychiatry. 1995; 166: 654-659
- Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression.Neuropsychopharmacology. 2008; 33: 368-377
- Immediate cerebral metabolic changes induced by discontinuation of deep brain stimulation of subcallosal cingulate gyrus in treatment-resistant depression.J Affect Disord. 2015; 173: 159-162
- Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder.Arch Gen Psychiatry. 2010; 67: 1061-1068
Article info
Publication history
Published online: September 22, 2018
Identification
Copyright
© 2018 Society of Biological Psychiatry.