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Article info
Publication history
Accepted:
July 18,
2018
Received:
July 17,
2018
Identification
Copyright
© 2018 Society of Biological Psychiatry.
ScienceDirect
Access this article on ScienceDirectLinked Article
- AMPA Receptor Activation–Independent Antidepressant Actions of Ketamine Metabolite (S)-NorketamineBiological PsychiatryVol. 84Issue 8
- PreviewKetamine, an N-methyl-D-aspartate receptor antagonist, exerts robust antidepressant effects in patients with treatment-resistant depression. The precise mechanisms underlying ketamine’s antidepressant actions remain unclear, although previous research suggests that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) activation plays a role. We investigated whether (S)-norketamine and (R)-norketamine, the two main metabolites of (R,S)-ketamine, also play a significant role in ketamine’s antidepressant effects and whether the effects are mediated by AMPAR.
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