Defining the Role of Interneuron N-Methyl-D-Aspartate Receptors in Prefrontal Cortex Inhibition

  • Robert W. Greene
    Address correspondence to Robert W. Greene, M.D., Ph.D., Peter O’Donnell Brain Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9070.
    Peter O’Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas
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        • Choi D.W.
        • Monyer H.
        • Giffard R.G.
        • Goldberg M.P.
        • Christine C.W.
        Acute brain injury, NMDA receptors, and hydrogen ions: Observations in cortical cell cultures.
        Adv Exp Med Biol. 1990; 268: 501-504
        • Olney J.W.
        • Labruyere J.
        • Wang G.
        • Wozniak D.F.
        • Price M.T.
        • Sesma M.A.
        NMDA antagonist neurotoxicity: Mechanism and prevention.
        Science. 1991; 254: 1515-1518
        • Coyle J.T.
        The glutamatergic dysfunction hypothesis for schizophrenia.
        Harv Rev Psychiatry. 1996; 3: 241-253
        • Krystal J.H.
        • Karper L.P.
        • Seibyl J.P.
        • Freeman G.K.
        • Delaney R.
        • Bremner J.D.
        • et al.
        Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
        Arch Gen Psychiatry. 1994; 51: 199-214
        • Javitt D.C.
        • Zukin S.R.
        Recent advances in the phencyclidine model of schizophrenia.
        Am J Psychiatry. 1991; 148: 1301-1308
        • Grunze H.C.
        • Rainnie D.G.
        • Hasselmo M.E.
        • Barkai E.
        • Hearn E.F.
        • McCarley R.W.
        • et al.
        NMDA-dependent modulation of CA1 local circuit inhibition.
        J Neurosci. 1996; 16: 2034-2043
        • Homayoun H.
        • Moghaddam B.
        NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons.
        J Neurosci. 2007; 27: 11496-11500
        • Pafundo D.E.
        • Miyamae T.
        • Lewis D.A.
        • Gonzalez-Burgos G.
        Presynaptic effects of N-methyl-D-aspartate receptors enhance parvalbumin cell–mediated inhibition of pyramidal cells in mouse prefrontal cortex.
        Biol Psychiatry. 2018; 84: 460-470

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