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Missed Connections: A Network Approach to Understanding Psychiatric Illness

  • Aaron F. Alexander-Bloch
    Correspondence
    Address correspondence to Aaron F. Alexander-Bloch, M.D., Ph.D., M.Phil., Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511.
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
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  • Danielle S. Bassett
    Affiliations
    Departments of Bioengineering and Electrical and Systems Engineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania

    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

    Department of Physics and Astronomy, College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania
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  • David A. Ross
    Affiliations
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
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      SEE CORRESPONDING ARTICLE ON PAGE 116
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      References

        • Collin G.
        • Turk E.
        • van den Heuvel M.P.
        Connectomics in schizophrenia: from early pioneers to recent brain network findings.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2016; 1: 199-208
        • Johnstone E.C.
        • Crow T.J.
        • Frith C.D.
        • Husband J.
        • Kreel L.
        Cerebral ventricular size and cognitive impairment in chronic schizophrenia.
        Lancet. 1976; 2: 924-926
        • Glausier J.R.
        • Lewis D.A.
        Dendritic spine pathology in schizophrenia.
        Neuroscience. 2013; 251: 90-107
        • Schizophrenia Working Group of the Psychiatric Genomics Consortium
        Biological insights from 108 schizophrenia-associated genetic loci.
        Nat Neurosci. 2014; 511: 421-427
        • Biswal B.
        • Yetkin F.Z.
        • Haughton V.M.
        • Hyde J.S.
        Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.
        Magn Reson Med. 1995; 34: 537-541
        • Raichle M.E.
        • MacLeod A.M.
        • Snyder A.Z.
        • Powers W.J.
        • Gusnard D.A.
        • Shulman G.L.
        A default mode of brain function.
        Proc Natl Acad Sci U S A. 2001; 98: 676-682
        • Bullmore E.
        • Sporns O.
        Complex brain networks: Graph theoretical analysis of structural and functional systems.
        Nat Rev Neurosci. 2009; 10: 186-198
        • Fornito A.
        • Bullmore E.T.
        • Zalesky A.
        Opportunities and challenges for psychiatry in the connectomic era.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2017; 2: 9-19
        • Reinwald J.R.
        • Becker R.
        • Mallien A.S.
        • Falfan-Melgoza C.
        • Sack M.
        • Clemm von Hohenberg C.
        • et al.
        Neural mechanisms of early-life social stress as a developmental risk factor for severe psychiatric disorders.
        Biol Psychiatry. 2018; 84: 116-128
        • Bassett D.S.
        • Sporns O.
        Network neuroscience.
        Nat Neurosci. 2017; 20: 353-364

      Linked Article

      • Neural Mechanisms of Early-Life Social Stress as a Developmental Risk Factor for Severe Psychiatric Disorders
        Biological PsychiatryVol. 84Issue 2
        • Preview
          To explore the domain-general risk factor of early-life social stress in mental illness, rearing rodents in persistent postweaning social isolation has been established as a widely used animal model with translational relevance for neurodevelopmental psychiatric disorders such as schizophrenia. Although changes in resting-state brain connectivity are a transdiagnostic key finding in neurodevelopmental diseases, a characterization of imaging correlates elicited by early-life social stress is lacking.
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      • Erratum
        Biological PsychiatryVol. 85Issue 7
        • Preview
          Erratum to: “Missed Connections: A Network Approach to Understanding Psychiatric Illness,” by Alexander-Bloch et al. (Biol Psychiatry 2018; 84:e9–e11); 10.1016/j.biopsych.2018.05.018 .
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