Identification of Human Hippocampal Circuitry Involved in Risk and Resilience to Posttraumatic Stress Disorder Following Trauma Exposure

  • Anthony P. King
    Address correspondence to Anthony P. King, Ph.D., Department of Psychiatry, Trauma, Stress, and Anxiety Research Program, University of Michigan Medical School, 2747 Rachel Upjohn Building, 4250 Plymouth Road, Ann Arbor, MI 48105.
    Department of Psychiatry, Trauma, Stress, and Anxiety Research Program, University of Michigan Medical School, Ann Arbor, Michigan
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        • van Rooij S.J.H.
        • Stevens J.S.
        • Ely T.D.
        • Hinrichs R.
        • Michopoulos V.
        • Winters S.J.
        • et al.
        The role of the hippocampus in predicting future posttraumatic stress disorder symptoms in recently traumatized civilians.
        Biol Psychiatry. 2018; 84: 106-115
        • Garfinkel S.N.
        • Abelson J.L.
        • King A.P.
        • Sripada R.K.
        • Wang X.
        • Gaines L.M.
        • et al.
        Impaired contextual modulation of memories in PTSD: An fMRI and psychophysiological study of extinction retention and fear renewal.
        J Neurosci. 2014; 34: 13435-13443
        • Liberzon I.
        • Abelson J.L.
        Context processing and the neurobiology of post-traumatic stress disorder.
        Neuron. 2016; 92: 14-30
        • Pitman R.K.
        • Rasmusson A.M.
        • Koenen K.C.
        • Shin L.M.
        • Orr S.P.
        • Gilbertson M.W.
        • et al.
        Biological studies of post-traumatic stress disorder.
        Nat Rev Neurosci. 2012; 13: 769-787
        • Logue M.W.
        • van Rooij S.J.H.
        • Dennis E.L.
        • Davis S.L.
        • Hayes J.P.
        • Stevens J.S.
        • et al.
        Smaller hippocampal volume in posttraumatic stress disorder: A multisite ENIGMA-PGC study: Subcortical volumetry results from posttraumatic stress disorder consortia.
        Biol Psychiatry. 2018; 83: 244-253
        • Bonne O.
        • Brandes D.
        • Gilboa A.
        • Gomori J.M.
        • Shenton M.E.
        • Pitman R.K.
        • et al.
        Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD.
        Am J Psychiatry. 2001; 158: 1248-1251
        • Stevens J.S.
        • Kim Y.J.
        • Galatzer-Levy I.R.
        • Reddy R.
        • Ely T.D.
        • Nemeroff C.B.
        • et al.
        Amygdala reactivity and anterior cingulate habituation predict posttraumatic stress disorder symptom maintenance after acute civilian trauma.
        Biol Psychiatry. 2017; 81: 1023-1029
        • Wang X.
        • Xie H.
        • Cotton A.S.
        • Duval E.R.
        • Tamburrino M.B.
        • Brickman K.R.
        • et al.
        Preliminary study of acute changes in emotion processing in trauma survivors with PTSD symptoms.
        PLoS One. 2016; 11: e0159065
        • Badura-Brack A.
        • McDermott T.J.
        • Becker K.M.
        • Ryan T.J.
        • Khanna M.M.
        • Pine D.S.
        • et al.
        Attention training modulates resting-state neurophysiological abnormalities in posttraumatic stress disorder.
        Psychiatry Res Neuroimaging. 2018; 271: 135-141
        • Bomyea J.
        • Stein M.B.
        • Lang A.J.
        Interference control training for PTSD: A randomized controlled trial of a novel computer-based intervention.
        J Anxiety Disord. 2015; 34: 33-42

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