- Ad-Dab’bagh Y.
- Einarson D.
- Lyttelton O.
- Muehlboeck J.-S.
- Mok K.
- Ivanov O.
- et al.
Methods and Materials
Image Acquisition and Processing
Widespread Thinner Cortex With Regional Specificity in Schizophrenia
Widespread Smaller Cortical Surface Area Without Regional Specificity in Schizophrenia
Partial Correlations With Age of Onset and Duration of Illness
Effects of Antipsychotic Medications on Cortical Thickness
Partial Correlations With Medication Dose
Partial Correlations With Symptom Severity Scores
- Tiihonen J.
- Walhbeck K.
- Lönnqvist J.
- Klaukka T.
- Ioannidis J.P.A.
- Volavka J.
- Haukka J.
Acknowledgments and Disclosures
- Supplemental Material
- Supplemental Table S1C
- A magnetic resonance imaging family study of cortical thickness in schizophrenia.Am J Med Genet B Neuropsychiatr Genet. 2015; 168: 660-668
- Regionally localized thinning of the cerebral cortex in schizophrenia.Arch Gen Psychiatry. 2003; 60: 878-888
- High-resolution random mesh algorithms for creating a probabilistic 3D surface atlas of the human brain.Neuroimage. 1996; 3: 19-34
- Bayesian construction of geometrically based cortical thickness metrics.Neuroimage. 2000; 12: 676-687
- Measurement of cortical thickness using an automated 3-D algorithm: A validation study.Neuroimage. 2001; 13: 375-380
- Automatic “pipeline” analysis of 3-D MRI data for clinical trials: Application to multiple sclerosis.IEEE Trans Med Imaging. 2002; 21: 1280-1291
- Cortical thickness analysis examined through power analysis and a population simulation.Neuroimage. 2005; 24: 163-173
- The CIVET image-processing environment: A fully automated comprehensive pipeline for anatomical neuroimaging research.in: Corbetta M. Proceedings of the 12th Annual Meeting of the Organization for Human Brain Mapping. NeuroImage, Florence, Italy2006
- FreeSurfer.Neuroimage. 2012; 62: 774-781
- Identification of common variants associated with human hippocampal and intracranial volumes.Nat Genet. 2012; 44: 552-561
- The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data.Brain Imaging Behav. 2014; 8: 153-182
- ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.Neuroimage. 2017; 145: 389-408
- Distinct genetic influences on cortical surface area and cortical thickness.Cereb Cortex. 2009; 19: 2728-2735
- Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies.Neuroimage. 2010; 53: 1135-1146
- Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder.Biol Psychiatry. 2010; 68: 41-50
- Changes in cortical thickness during the course of illness in schizophrenia.Arch Gen Psychiatry. 2011; 68: 871-880
- Distinct patterns of cerebral cortical thinning in schizophrenia: A neuroimaging data-driven approach.Schizophr Bull. 2017; 43: 900-906
- Complex pattern of cortical thinning in schizophrenia: Results from an automated surface based analysis of cortical thickness.Psychiatry Res. 2010; 182: 134-140
- Cortical thinning in cingulate and occipital cortices in first episode schizophrenia.Biol Psychiatry. 2005; 58: 32-40
- Mapping cortical thickness and gray matter concentration in first episode schizophrenia.Cereb Cortex. 2005; 15: 708-719
- Surface-based morphometry of the anterior cingulate cortex in first episode schizophrenia.Hum Brain Mapp. 2008; 29: 478-489
- Brain surface contraction mapped in first-episode schizophrenia: A longitudinal magnetic resonance imaging study.Mol Psychiatry. 2009; 14: 976-986
- Global and regional cortical thinning in first-episode psychosis patients: Relationships with clinical and cognitive features.Psychol Med. 2011; 41: 1449-1460
- A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia.JAMA Psychiatry. 2015; 72: 226-234
- A comparison of neuroimaging findings in childhood onset schizophrenia and autism spectrum disorder: A review of the literature.Front Psychiatry. 2013; 4: 175
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophr Res. 2016; 173: 124-131
- Evidence for abnormalities of cortical development in adolescent-onset schizophrenia.Neuroimage. 2008; 43: 665-675
- Automated MRI parcellation study of regional volume and thickness of prefrontal cortex (PFC) in antipsychotic-naïve schizophrenia.Acta Psychiatr Scand. 2008; 117: 420-431
- Brain volume reductions in medication-naive patients with schizophrenia in relation to intelligence quotient.Psychol Med. 2012; 42: 1847-1856
- A combined DTI and structural MRI study in medicated-naïve chronic schizophrenia.Magn Reson Imaging. 2014; 32: 1-8
- Cortical thickness in individuals with non-clinical and clinical psychotic symptoms.Brain. 2014; 137: 2664-2669
- Can cortical thickness asymmetry analysis contribute to detection of at-risk mental state and first-episode psychosis? A pilot study.Radiology. 2009; 250: 212-221
- Progressive brain structural changes mapped as psychosis develops in “at risk” individuals.Schizophr Res. 2009; 108: 85-92
- Cortical thickness reduction in individuals at ultra-high-risk for psychosis.Schizophr Bull. 2011; 37: 839-849
- Neuromagnetic auditory response and its relation to cortical thickness in ultra-high-risk for psychosis.Schizophr Res. 2012; 140: 93-98
- Using structural neuroimaging to make quantitative predictions of symptom progression in individuals at ultra-high risk for psychosis.Front Psychiatry. 2013; 4: 187
- Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis.Psychol Med. 2014; 44: 489-498
- Progressive reduction in cortical thickness as psychosis develops: A multisite longitudinal neuroimaging study of youth at elevated clinical risk.Biol Psychiatry. 2015; 77: 147-157
- Mapping structural covariance networks of facial emotion recognition in early psychosis: A pilot study.Schizophr Res. 2017; 189: 146-152
- Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.Mol Psychiatry. 2016; 21: 547-553
- Abnormal asymmetries in subcortical brain volume in schizophrenia.Mol Psychiatry. 2016; 21: 1460-1466
- Psychosis and brain volume changes during the first five years of schizophrenia.Eur Neuropsychopharmacol. 2009; 19: 147-151
- Psychotic symptoms and gray matter deficits in clinical pediatric populations.Schizophr Res. 2012; 140: 149-154
- Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrum.Cereb Cortex. 2013; 23: 61-70
- Correlations between brain structure and symptom dimensions of psychosis in schizophrenia, schizoaffective, and psychotic bipolar I disorders.Schizophr Bull. 2015; 41: 154-162
- Altered cortical thickness related to clinical severity but not the untreated disease duration in schizophrenia.Schizophr Bull. 2013; 41: 201-210
- Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.Acta Psychiatr Scand. 2017; 135: 439-447
- Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.Psychol Med. 2018; 48: 82-94
- Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings.Psychol Med. 2009; 39: 1763-1777
- Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies.Neurosci Biobehav Rev. 2013; 37: 1680-1691
- The effect of antipsychotic treatment on cortical gray matter changes in schizophrenia: Does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies.Biol Psychiatry. 2015; 78: 403-412
- The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.Schizophr Bull. 1987; 13: 261-276
- Scale for the Assessment of Negative Symptoms: SANS.University of Iowa, Iowa City1984
- The Scale for the Assessment of Positive Symptoms (SAPS).University of Iowa, Iowa City1984
- An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.Neuroimage. 2006; 31: 968-980
- Conducting meta-analyses in R with the metafor Package.J Stat Softw. 2010; 36: 1-48
- Controlling the false discovery rate: A practical and powerful approach to multiple testing.J R Stat Soc Series B Stat Methodol. 1995; 57: 289-300
- Time-lapse mapping of cortical changes in schizophrenia with different treatments.Cereb Cortex. 2009; 19: 1107-1123
- Long-term antipsychotic treatment and brain volumes: A longitudinal study of first-episode schizophrenia.Arch Gen Psychiatry. 2011; 68: 128-137
- Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis.Psychol Med. 2015; 45: 515-527
- Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia.Schizophr Res. 2016; 173: 192-199
- Antipsychotic drug effects on brain morphology in first-episode psychosis.Arch Gen Psychiatry. 2005; 62: 361
- Reduced cortical volume and elevated astrocyte density in rats chronically treated with antipsychotic drugs—linking magnetic resonance imaging findings to cellular pathology.Biol Psychiatry. 2014; 75: 982-990
- Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia.Schizophr Res. 2009; 108: 49-56
- Initial and progressive gray matter abnormalities in insular gyrus and temporal pole in first-episode schizophrenia contrasted with first-episode affective psychosis.Schizophr Bull. 2016; 42: 790-801
- Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis.Schizophr Res. 2009; 111: 94-102
- Mapping cortical change across the human life span.Nat Neurosci. 2003; 6: 309-315
- Genetic insights into the neurodevelopmental origins of schizophrenia.Nat Rev Neurosci. 2017; 18: 727-740
- Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: Randomised controlled trial.BMJ. 2010; 341: c4024
- Effectiveness of antipsychotic treatments in a nationwide cohort of patients in community care after first hospitalisation due to schizophrenia and schizoaffective disorder: Observational follow-up study.BMJ. 2006; 333: 224
- Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.Mol Psychiatry. 2018; 23: 932-942
- Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group.Mol Psychiatry. 2017; 22: 900-909
Members of the Karolinska Schizophrenia Project: Lars Farde (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm County Council, Stockholm, Sweden), Lena Flyckt (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm County Council, Stockholm, Sweden), Göran Engberg (Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden), Sophie Erhardt (Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden), Helena Fatouros-Bergman (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm County Council, Stockholm, Sweden), Simon Cervenka (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm County Council, Stockholm, Sweden), Lilly Schwieler (Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden), Fredrik Piehl (Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden), Ingrid Agartz (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm County Council, Stockholm, Sweden; NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo; Department of Psychiatry Research, Diakonhjemmet Hospital, Oslo, Norway), Karin Collste (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm County Council, Stockholm, Sweden), Pauliina Victorsson (Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm County Council, Stockholm, Sweden), Anna Malmqvist (Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden), Mikael Hedberg (Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden), and Funda Orhan (Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden).
User LicenseCreative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) |
For non-commercial purposes:
- Read, print & download
- Redistribute or republish the final article
- Text & data mine
- Translate the article (private use only, not for distribution)
- Reuse portions or extracts from the article in other works
- Sell or re-use for commercial purposes
- Distribute translations or adaptations of the article
Elsevier's open access license policy