Searching for Replicable Dopamine-Related Findings in Gambling Disorder

  • Marc N. Potenza
    Address correspondence to Marc N. Potenza, M.D., Ph.D., Yale University School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, CT 06519.
    Departments of Psychiatry and Neuroscience and Child Study Center, Yale School of Medicine, and the Connecticut Mental Health Center, New Haven, Connecticut
    Connecticut Council on Problem Gambling, Wethersfield, Connecticut
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      Linked Article

      • Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction
        Biological PsychiatryVol. 83Issue 12
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          The hypothesis that dopamine plays an important role in the pathophysiology of pathological gambling is pervasive. However, there is little to no direct evidence for a categorical difference between pathological gamblers and healthy control subjects in terms of dopamine transmission in a drug-free state. Here we provide evidence for this hypothesis by comparing dopamine synthesis capacity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 healthy control subjects.
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