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So Happy Together: The Storied Marriage Between Mitochondria and the Mind

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      Linked Article

      • Mitochondrial Etiology of Neuropsychiatric Disorders
        Biological PsychiatryVol. 83Issue 9
        • Preview
          The brain has the highest mitochondrial energy demand of any organ. Therefore, subtle changes in mitochondrial energy production will preferentially affect the brain. Considerable biochemical evidence has accumulated revealing mitochondrial defects associated with neuropsychiatric diseases. Moreover, the mitochondrial genome encompasses over a thousand nuclear DNA genes plus hundreds to thousands of copies of the maternally inherited mitochondrial DNA (mtDNA). Therefore, partial defects in either the nuclear DNA or mtDNA genes or combinations of the two can be sufficient to cause neuropsychiatric disorders.
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