S105. Adiponectin Moderates Antidepressant Treatment Response in the CO-MED Randomized Clinical Trial

      Major depressive disorder (MDD) is a complex psychiatric disorder that is often comorbid with metabolic diseases such as obesity, cardiovascular disease, and type II diabetes. A potential link between these disorders is adiponectin, an adipocyte-derived circulating hormone with insulin-sensitizing, anti-inflammatory, and neuroplasticity effects. Reductions in plasma levels of adiponectin have been reported in both humans with depression and in the chronic-defeat mouse model of depression. However, the predictive value of adiponectin for treatment response to depression has not been determined.
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