S88. Young Male ‘Owls’ Present With Decreased Levels of Brain-Derived Neurotrophic Factor: Increased Risk for Depression?

      Brain-derived neurotrophic factor (BDNF) is involved in neuroplasticity, and decreased BDNF activity is related to pathophysiology of depression. Moreover, BDNF follows a circadian rhythm with a peak early after awakening and a gradually decline thereafter. The aim of this study was to examine, if BDNF serum levels (BDNF i. s.) in the afternoon would depend on the chronotype. We expected a phase advance in healthy ‘owls’ with higher BDNF serum levels in the afternoon than in ‘larks’.
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