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S53. Combined Resting State fMRI and EEG Investigation of Irritability

      Irritability symptoms are an important dimension of Oppositional Defiant Disorder (ODD) that often persist through adolescence and are associated with increased risk for depression and anxiety into adulthood. Yet the neurobiology associated with the irritability dimension of ODD is poorly understood. Initial fMRI evidence provides support for differences in functional connectivity related to deficits in cognitive control and emotional liability, yet results have differed across tasks and previous studies have not sufficiently distinguish between specific disruptive behavior disorders or subtypes of behavioral problems. Resting State Functional Connectivity (RSFC) provides a basis for investigating the neural basis of activity in brain regions of interest (ROIs) independent of task stimulation.
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