Irritability symptoms are an important dimension of Oppositional Defiant Disorder
(ODD) that often persist through adolescence and are associated with increased risk
for depression and anxiety into adulthood. Yet the neurobiology associated with the
irritability dimension of ODD is poorly understood. Initial fMRI evidence provides
support for differences in functional connectivity related to deficits in cognitive
control and emotional liability, yet results have differed across tasks and previous
studies have not sufficiently distinguish between specific disruptive behavior disorders
or subtypes of behavioral problems. Resting State Functional Connectivity (RSFC) provides
a basis for investigating the neural basis of activity in brain regions of interest
(ROIs) independent of task stimulation.
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© 2018 Published by Elsevier Inc.
