ALKS 5461 is an investigational opioid system modulator for adjunctive treatment of
major depressive disorder (MDD) comprised of buprenorphine (BUP) and samidorphan (SAM),
a μ-opioid receptor antagonist added to address the abuse/dependence potential of
BUP. The ability of SAM to address the abuse potential of BUP in the ALKS 5461 combination
was explored.
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© 2018 Published by Elsevier Inc.
