Veterans are at increased risk of developing PTSD resulting from a number of factors including military-related combat. Structural and functional neuroimaging studies in patients with PTSD have demonstrated alterations in the anterior cingulate cortex (ACC). Altered Gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter and modulator of neuronal excitability, has been implicated in PTSD. However, studies of ACC GABA in veterans are scarce. The current study investigated differences in GABA in veterans with and without PTSD using proton magnetic resonance spectroscopy (1H-MRS).
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