Lithium is thought to improve white matter (WM) integrity in bipolar disorder (BD)
because diffusion weighted imaging shows higher fractional anisotropy (FA) values
in those taking the drug. Interpretation of this observation would be aided by tissue-level
determination of brain lithium concentration. In vivo lithium magnetic resonance spectroscopy
(7Li-MRS) requires long acquisition times but as 7Li yields a spectral singlet, advanced
magnetic resonance imaging (MRI) techniques can be applied.
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