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240. Extracellular Free Water and Glutathione in First Episode Schizophrenia and a Non-Human Primate Model of Maternal Immune Activation – Exploring Neuroimmune Mechanisms of Psychiatric Disorders

      Recent work highlights an immune-based component of psychiatric disorder etiology, particularly schizophrenia. We evaluated two putative biomarkers of neuroinflammation—diffusion MRI free water (FW) and 1H-MRS Glutathione (GSH)—in a first episode schizophrenia (SZ) sample. Furthermore, we developed a non-human primate (NHP) model of maternal immune activation (MIA) to test that maternal immune response contributes to parallel brain changes in developing NHP offspring.
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