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136. Temporal Development of Depression Biomarkers From the iSPOT-D Study: State or Trait

      In the quest for improving treatment prediction in depression, several promising prognostic baseline biomarkers for escitalopram, venlafaxine and sertraline have been identified, including frontal alpha asymmetry (FAA) and paroxysmal activity. As confirmed in our recent meta-analysis, FAA is not different between patients with and without depression, and hence it is hypothesized that FAA has state-independent characteristics. Differences in medication response in patients with paroxysmal EEG activity suggest a possible anticonvulsant property of sertraline relative to other antidepressants.
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