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134. Optimizing TMS Treatment for Depression Using Cardiac Response With Neuro-Cardiac-Guided-TMS (NCG TMS)

      The efficacy of repetitive-Transcranial-Magnetic-Stimulation (rTMS), targeted at the Dorsolateral-Prefrontal-Cortex (DLPFC), to treat depression, has been well established. However, most studies haven’t employed individualized methods. One way to individualize treatment is target engagement, by employing a functional outcome measure to verify localization. Given that DLPFC-TMS exerts its clinical benefit through connectivity with the subgenual-Anterior-Cingulate-Cortex (sgACC), we aimed to develop a method based on the role of the sgACC in autonomic regulation, particularly heart rate control. It has been demonstrated that stimulation of the sgACC and the DLPFC leads to heart rate decelerations, suggesting heart rate might serve as functional outcome measure.
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