The efficacy of repetitive-Transcranial-Magnetic-Stimulation (rTMS), targeted at the
Dorsolateral-Prefrontal-Cortex (DLPFC), to treat depression, has been well established.
However, most studies haven’t employed individualized methods. One way to individualize
treatment is target engagement, by employing a functional outcome measure to verify
localization. Given that DLPFC-TMS exerts its clinical benefit through connectivity
with the subgenual-Anterior-Cingulate-Cortex (sgACC), we aimed to develop a method
based on the role of the sgACC in autonomic regulation, particularly heart rate control.
It has been demonstrated that stimulation of the sgACC and the DLPFC leads to heart
rate decelerations, suggesting heart rate might serve as functional outcome measure.
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© 2018 Published by Elsevier Inc.
