49. Endocannabinoid System in Posttraumatic Stress Disorder (PTSD) Early After Traumatic Injury

      In the immediate aftermath of injury it is unclear who demonstrates risk for posttraumatic stress disorder (PTSD). Pre-clinical data suggests the endocannabinoid signaling system responds to stress and acts as a buffer after trauma. The purpose of the present study was: 1) evaluate the role of early circulating endocannabinoid (2-AG, AEA) functioning in 6-month PTSD, and 2) evaluate polymorphisms of the cannabinoid receptor type 1 (CB1) and fatty acid amide hydrolase (FAAH) genes to determine differential PTSD risk. Based on preclinical data, we hypothesized lower 2-AG and AEA acutely after injury would confer risk for PTSD.
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