40. From Biomarker Candidates to a New Therapeutic Intervention for Pain

      Chronic low back pain (CLBP) is highly prevalent in Iraq/Afghanistan-era Veterans, and diagnoses of this potentially disabling condition are increasing in the VA at a rate of about 5% each year. The effective treatment of CLBP symptoms is thus of paramount importance, and new therapeutic agents that are non-habit forming, safe, and efficacious are urgently needed. Our prior investigations examining neurosteroids as biomarker candidates of self-reported pain symptoms suggest that dysregulation of these molecules may contribute to the pathophysiology of pain symptoms (Kilts et al., 2010, Naylor et al 2016), and that ameliorating these deficits could be clinically therapeutic.
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