Advertisement

40. From Biomarker Candidates to a New Therapeutic Intervention for Pain

      Chronic low back pain (CLBP) is highly prevalent in Iraq/Afghanistan-era Veterans, and diagnoses of this potentially disabling condition are increasing in the VA at a rate of about 5% each year. The effective treatment of CLBP symptoms is thus of paramount importance, and new therapeutic agents that are non-habit forming, safe, and efficacious are urgently needed. Our prior investigations examining neurosteroids as biomarker candidates of self-reported pain symptoms suggest that dysregulation of these molecules may contribute to the pathophysiology of pain symptoms (Kilts et al., 2010, Naylor et al 2016), and that ameliorating these deficits could be clinically therapeutic.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect