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38. GABAergic Neurosteroids in Cerebrospinal Fluid are Negatively Associated With PTSD Severity in Men

      Previous research demonstrated decreases in the GABAergic neurosteroids allopregnanolone and pregnanolone (together termed ALLO) in the cerebrospinal fluid (CSF) of women with PTSD, which correlated with PTSD re-experiencing and depression symptoms. A low ratio of ALLO to 5-alpha-dihydroprogesterone (a steroid precursor), indicated a block in ALLO synthesis catalyzed by the 3-alpha-hydroxysteroid dehydrogenase enzyme. Recent research in women with PTSD confirmed the site of this block in plasma, as well as a PTSD-related deficit in the capacity to increase ALLO synthesis during stress.
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