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35. Heterogeneity in First Episode Psychosis, and Prediction of Progression

      Difficulties in the prediction of outcome after the onset of psychosis are linked to the high clinical and biological heterogeneity of this disorder. Subtle and diffuse alterations in brain structure are already present at the onset, but seem to characterise those patients with particularly poor outcome. Large multi-centre MRI studies can provide the scale needed to identify the neuroimaging markers specifically associated with clinical outcomes.
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