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24. Biomarker Development in ASD: Electrophysiological Response During Auditory Gap Detection is Associated With Symptom Severity and May Index Excitatory/Inhibitory Imbalance

      Several rare genetic disorders that result in an ASD phenotype (e.g., Fragile X syndrome, Phelan-McDermid syndrome) implicate alterations in excitatory/inhibitory neurotransmitter balance. Recently, the search for sensitive and reliable biomarkers indexing specific neural processes and relevant for measuring treatment response has intensified in ASD research. Auditory gap detection is a low-level sensory function that: a) is impaired in ASD and other communication disorders, b) is sensitive to perturbations in E/I balance, and c) can be indexed with electrophysiology (EEG). This study tested whether electrophysiological response during gap detection is impaired in ASD, associated with clinical variables, and a potentially viable biomarker for ASD.
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