22. Non-Word Memory in Rett Syndrome and Rett-Related Disorders

      Despite significant advances at the level of basic research that have progressed to treatment trials, sensitive biomarkers of higher-level cognitive and language processing deficits in Rett and RTT-related disorders remain elusive. To test whether EEG could be used to dissociate capacity for auditory learning and memory, we assessed how children with RTT and MECP2 duplication syndrome became familiarized with a repeatedly presented spoken non-word, testing whether differentiation of familiarized vs. novel non-word stimuli could be detected with event-related potentials (ERP).
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