17. Lifelong Transcriptional, Epigenetic, and Neurophysiological Consequences of Early Life Stress in Mouse Brain Reward Circuitry

      Abuse, neglect, and other forms of early life stress (ELS) increase risk for depression. We recently established a “two-hit” stress paradigm in male and female mice, and found a sensitive period for postnatal stress to increase risk that stress in adulthood results in depression-like behavior. We sought to understand the long-lasting consequences of ELS on reward circuitry at transcriptional, epigenetic, and neurophysiological levels.
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