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16. Synaptic Mechanisms in 16p11.2 Duplication Model Mice

      Duplications of 16p11.2 chromosomal region, found in autism spectrum disorders (ASD), schizophrenia (SZ), intellectual disability (ID), Rolandic epilepsy, and other disorders, are among the top CNVs in SZ. Alterations in glutamatergic synapses are key pathogenic mechanisms in SZ, ASD, and ID; yet how synaptic biology contributes to the pathogenesis of CNV disorders remains largely elusive.
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