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15. The Tetrapartite Synapse in Schizophrenia: Role of the Extracellular Matrix and Glial Cell in PSD Pathology

      The ‘tetrapartite synapse’, comprised of the pre- and post-synaptic elements, glia and the extracellular matrix (ECM), may represent a useful concept to investigate synaptic abnormalities in schizophrenia (SZ). Interactions between the ECM, which forms organized perisynaptic aggregates, and glial cell have been shown to regulate synaptic functions and plasticity. These mechanisms are mediated by ECM remodeling proteases, such as matrix metallo proteases (MMPs) and cathepsin S. We tested the hypothesis that previously shown decreases of perineuronal nets (PNNs), a form of perisynaptic ECM, and CS-6/Glia clusters, an ECM structure enriched in 6-sulfated chondroitin sulfate proteoglycans, in SZ may be at least in part due to a disregulation of ECM remodeling proteases. Studies in human and rodents assessed the relationship between CS-6 expression, glia and synapses.
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