13. Dysregulation of Coding and Non-Coding Transcripts Points to Synaptic Abnormalities in Schizophrenia

      Transcription of enhancer RNAs (eRNAs) takes place at a broad range of regulatory sequences in an activity dependent manner. A subset of putative enhancers enriched in disease-associated variants is often transcriptionally active in pathologically relevant cell types. It is unclear whether the alteration of eRNA transcription: (i) has an active role in disease-associated enhancer malfunction and (ii) drives downstream dysregulation in coding transcripts.
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