Advertisement

13. Dysregulation of Coding and Non-Coding Transcripts Points to Synaptic Abnormalities in Schizophrenia

      Transcription of enhancer RNAs (eRNAs) takes place at a broad range of regulatory sequences in an activity dependent manner. A subset of putative enhancers enriched in disease-associated variants is often transcriptionally active in pathologically relevant cell types. It is unclear whether the alteration of eRNA transcription: (i) has an active role in disease-associated enhancer malfunction and (ii) drives downstream dysregulation in coding transcripts.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect