11. Orexin-1 Receptor Antagonists as Novel Smoking Cessation Agents

      Orexin-1 receptors (OX1Rs) regulate the motivation to seek and consume nicotine in laboratory rodents, but underlying mechanisms are unclear. Here, we identify a novel brain circuit through which OX1Rs exerts control over nicotine-seeking behaviors. We also describe progress toward developing patient-ready OX1R antagonists as novel smoking cessation agents.
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