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Bipolar Disorder as a Mitochondrial Disease

  • Ana C. Andreazza
    Correspondence
    Address correspondence to Ana C. Andreazza, Pharm. Ph.D., University of Toronto, Department of Pharmacology, 1 King’s College Circle, Room 4204, Toronto, ON M5S1A8, Canada.
    Affiliations
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

    Department Psychiatry, University of Toronto, Toronto, Ontario, Canada

    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
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  • Angela Duong
    Affiliations
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
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  • L. Trevor Young
    Affiliations
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

    Department Psychiatry, University of Toronto, Toronto, Ontario, Canada

    Centre for Addiction and Mental Health, Toronto, Ontario, Canada
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Published:September 27, 2017DOI:https://doi.org/10.1016/j.biopsych.2017.09.018
      Relapse, recurrence, and psychosis are common features in bipolar disorder (BD), affecting all aspects of an individual’s life with repercussions for the overall economy. BD is further compounded by the lack of measurable biological markers because current diagnosis relies largely on subjectively documenting mood and behavior. Without a thorough understanding of the underlying target biology of BD, the diagnosis, management, prevention, and treatment of this debilitating condition will remain an unsolved challenge, inflicting continued substantial burden on health care costs.
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