Clinical Commentary| Volume 82, ISSUE 8, e61-e63, October 15, 2017

Your System Has Been Hijacked: The Neurobiology of Chronic Pain

      –C.S. Lewis
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        • Institute of Medicine (U.S.) Committee on Advancing Pain Research, Care, and Education
        Relieving Pain in America, A Blueprint for Transforming Prevention, Care, Education and Research.
        The National Academies Press, Washington, DC2011
      1. American Academy of Pain Medicine. Facts and figures on pain. Available at: Accessed July 31, 2017.

      2. Hellier J.L. The Five Senses and Beyond: The Encyclopedia of Perception. ABC-CLIO/Greenwood, Santa Barbara, CA2016: 118-119
        • Kandel E.R.
        • Schwartz J.H.
        • Jessell T.M.
        Principles of Neural Science. 4th ed. McGraw-Hill, Health Professions Division, New York2000: 471-490
        • Nolte J.
        The Human.
        Brain: An Introduction to its Functional Anatomy. 6th ed. Mosby, St. Louis, MO2002: 207-215
        • Basbaum A.I.
        • Bautista D.M.
        • Scherrer G.
        • Julius D.
        Cellular and molecular mechanisms of pain.
        Cell. 2009; 139: 267-284
        • Zhang H.
        • Qian Y.-L.
        • Li C.
        • Liu D.
        • Wang L.
        • Wang X.-Y.
        • et al.
        Brain-derived neurotrophic factor in the mesolimbic reward circuitry mediates nociception in chronic neuropathic pain.
        Biol Psychiatry. 2017; 82: 608-618
        • Schatzberg A.F.
        • Nemeroff C.B.
        The American Psychiatric Publishing Textbook of Psychopharmacology. 4th ed. American Psychiatric Publishing, Washington, DC2009: 1441-1469
      3. Murphy JL, McKellar JD, Raffa SD, Clark ME, Kerns RD, Karlin BE (2014): Cognitive Behavioral Therapy for Chronic Pain Among Veterans: Therapist Manual. Washington, DC: U.S. Department of Veterans Affairs.

      4. Centers for Disease Control and Prevention (2016): Drug overdose death data. Atlanta, Georgia. Available at: Accessed July 31, 2017.

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