Focus on Mitogen-Activated Kinase Phosphatase-1: Looking for the Roots of Depression in the Anterior Cingulate Cortex

  • Barbara Di Benedetto
    Address correspondence to Barbara Di Benedetto, Ph.D., University of Regensburg, Department of Psychiatry and Psychotherapy, Franz-Joseph-Strauss-Allee 11, 93053 Regensburg, Germany.
    Department of Psychiatry and Psychotherapy, Regensburg, Germany

    Regensburg Center of Neuroscience, University of Regensburg, Regensburg, Germany
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      Understanding the molecular and neuroanatomical underpinnings of mood disorders such as depression and anxiety may help to develop diagnostic tools or to identify alternative targets for drug discovery. Mood disorders share comorbidities with pain syndromes. Clinically, a principal mood disturbance can enhance pain perception, whereas primary pain pathologies can aggravate mood disorders. Such comorbidities can be studied in animal models, thereby offering alternative tools to investigate molecular mechanisms inducing depression and to support the development of tailored treatments for depressive patients.
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