Advertisement

Focus on Mitogen-Activated Kinase Phosphatase-1: Looking for the Roots of Depression in the Anterior Cingulate Cortex

  • Barbara Di Benedetto
    Correspondence
    Address correspondence to Barbara Di Benedetto, Ph.D., University of Regensburg, Department of Psychiatry and Psychotherapy, Franz-Joseph-Strauss-Allee 11, 93053 Regensburg, Germany.
    Affiliations
    Department of Psychiatry and Psychotherapy, Regensburg, Germany

    Regensburg Center of Neuroscience, University of Regensburg, Regensburg, Germany
    Search for articles by this author
      Understanding the molecular and neuroanatomical underpinnings of mood disorders such as depression and anxiety may help to develop diagnostic tools or to identify alternative targets for drug discovery. Mood disorders share comorbidities with pain syndromes. Clinically, a principal mood disturbance can enhance pain perception, whereas primary pain pathologies can aggravate mood disorders. Such comorbidities can be studied in animal models, thereby offering alternative tools to investigate molecular mechanisms inducing depression and to support the development of tailored treatments for depressive patients.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Barthas F.
        • Humo M.
        • Gilsbach R.
        • Waltisperger E.
        • Karatas M.
        • Leman S.
        • et al.
        Cingulate overexpression of mitogen-activated protein kinase phosphatase-1 as a key factor for depression.
        Biol Psychiatry. 2017; 82: 370-379
        • Missig G.
        • Mei L.
        • Vizzard M.A.
        • Braas K.M.
        • Waschek J.A.
        • Ressler K.J.
        • et al.
        Parabrachial pituitary adenylate cyclase-activating polypeptide activation of amygdala endosomal extracellular signal-regulated kinase signaling regulates the emotional component of pain.
        Biol Psychiatry. 2017; 81: 671-682
        • Zhuo M.
        Cortical excitation and chronic pain.
        Trends Neurosci. 2008; 31: 199-207
        • Zhuang Z.Y.
        • Gerner P.
        • Woolf C.J.
        • Ji R.R.
        ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model.
        Pain. 2005; 114: 149-159
        • Kumar V.
        • Zhang M.X.
        • Swank M.W.
        • Kunz J.
        • Wu G.Y.
        Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.
        J Neurosci. 2005; 25: 11288-11299
        • Rajkowska G.
        • Hughes J.
        • Stockmeier C.A.
        • Javier Miguel-Hidalgo J.
        • Maciag D.
        Coverage of blood vessels by astrocytic endfeet is reduced in major depressive disorder.
        Biol Psychiatry. 2013; 73: 613-621
        • Di Benedetto B.
        • Malik V.A.
        • Begum S.
        • Jablonowski L.
        • Gómez-González G.B.
        • Neumann I.D.
        • et al.
        Fluoxetine requires the endfeet protein aquaporin-4 to enhance plasticity of astrocyte processes.
        Front Cell Neurosci. 2016; 10: 62-73

      Linked Article