The search for genetic associations with depressive disorders has been long and frustrating.
Initial results with genome-wide association studies in psychiatric disorders in general
were widely regarded as disappointing when the method was first introduced in 2004
to 2006. It required about 8 years to move from early negative results to much more
positive results in schizophrenia and bipolar disorder, culminating in the remarkable
publication of 108 genome-wide significant loci in schizophrenia in 2014. The major
reason for success was sample size. The 2014 publication by the Schizophrenia Working
Group of the Psychiatric Genomics Consortium (
1
) included more than 30,000 cases of persons with schizophrenia and more than 100,000
control subjects. Initial unsuccessful genome-wide association studies in psychiatric
disorders started with about 1000 cases and 1000 control subjects.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Biological insights from 108 schizophrenia-associated genetic loci.Nature. 2014; 511: 421-427
- Sparse whole-genome sequencing identifies two loci for major depressive disorder.Nature. 2015; 523: 588-591
- An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype.Biol Psychiatry. 2017; 82: 322-329
- METAL: Fast and efficient metaanalysis of genomewide association scans.Bioinformatics. 2010; 26: 2190-2191
- Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey.J Affect Disord. 1997; 45: 19-30
- The subtypes of major depression in a twin registry.J Affect Disord. 2002; 68: 273-284
- The prevalence, clinical relevance, and public health significance of subthreshold depressions.Psychiatr Clin North Am. 2002; 25: 685-698
- Regions of variable DNA methylation in human placenta associated with newborn neurobehavior.Epigenetics. 2016; 11: 603-613
- Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.Biol Psychiatry. 2017; 81: 325-335
Article info
Publication history
Accepted:
June 21,
2017
Received:
June 20,
2017
Identification
Copyright
© 2017 Published by Elsevier Inc. on behalf of Society of Biological Psychiatry
ScienceDirect
Access this article on ScienceDirectLinked Article
- An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression PhenotypeBiological PsychiatryVol. 82Issue 5
- PreviewThe genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.
- Full-Text
- Preview