The search for genetic associations with depressive disorders has been long and frustrating.
Initial results with genome-wide association studies in psychiatric disorders in general
were widely regarded as disappointing when the method was first introduced in 2004
to 2006. It required about 8 years to move from early negative results to much more
positive results in schizophrenia and bipolar disorder, culminating in the remarkable
publication of 108 genome-wide significant loci in schizophrenia in 2014. The major
reason for success was sample size. The 2014 publication by the Schizophrenia Working
Group of the Psychiatric Genomics Consortium (
1
) included more than 30,000 cases of persons with schizophrenia and more than 100,000
control subjects. Initial unsuccessful genome-wide association studies in psychiatric
disorders started with about 1000 cases and 1000 control subjects.To read this article in full you will need to make a payment
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References
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Article info
Publication history
Accepted:
June 21,
2017
Received:
June 20,
2017
Identification
Copyright
© 2017 Published by Elsevier Inc. on behalf of Society of Biological Psychiatry
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- An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression PhenotypeBiological PsychiatryVol. 82Issue 5
- PreviewThe genetics of depression has been explored in genome-wide association studies that focused on either major depressive disorder or depressive symptoms with mostly negative findings. A broad depression phenotype including both phenotypes has not been tested previously using a genome-wide association approach. We aimed to identify genetic polymorphisms significantly associated with a broad phenotype from depressive symptoms to major depressive disorder.
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