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RETRACTED: Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement

  • David Soto
    Affiliations
    Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Department of Biomedicine, University of Barcelona, Barcelona, Spain

    August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain
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  • Mireia Olivella
    Affiliations
    Bioinfomatics and Medical Statistics Group, University of Vic–Central University of Catalonia, Barcelona, Spain
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  • Cristina Grau
    Affiliations
    Bellvitge Biomedical Research Institute–Unit of Neuropharmacology and Pain Group, University of Barcelona, Barcelona, Spain
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  • Judith Armstrong
    Affiliations
    Genetics and Molecular Medicine Service, Hospital Sant Joan de Déu and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain
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  • Clara Alcon
    Affiliations
    Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Department of Clinical Foundations, University of Barcelona, Barcelona, Spain
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  • Xavier Gasull
    Affiliations
    Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Department of Biomedicine, University of Barcelona, Barcelona, Spain

    August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain
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  • Macarena Gómez de Salazar
    Affiliations
    Bellvitge Biomedical Research Institute–Unit of Neuropharmacology and Pain Group, University of Barcelona, Barcelona, Spain
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  • Esther Gratacòs-Batlle
    Affiliations
    Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Department of Biomedicine, University of Barcelona, Barcelona, Spain

    August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain
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  • David Ramos-Vicente
    Affiliations
    Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, Barcelona, Spain

    Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
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  • Víctor Fernández-Dueñas
    Affiliations
    Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Department of Pathology and Experimental Therapeutics, University of Barcelona, Barcelona, Spain

    Bellvitge Biomedical Research Institute–Unit of Neuropharmacology and Pain Group, University of Barcelona, Barcelona, Spain
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  • Francisco Ciruela
    Affiliations
    Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Department of Pathology and Experimental Therapeutics, University of Barcelona, Barcelona, Spain

    Bellvitge Biomedical Research Institute–Unit of Neuropharmacology and Pain Group, University of Barcelona, Barcelona, Spain
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  • Àlex Bayés
    Affiliations
    Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, Barcelona, Spain

    Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
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  • Carlos Sindreu
    Affiliations
    Institute of Neurosciences, University of Barcelona, Barcelona, Spain

    Department of Clinical Foundations, University of Barcelona, Barcelona, Spain
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  • Anna López-Sala
    Affiliations
    Department of Neurology, Neurometabolic Unit, Hospital Sant Joan de Déu and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain
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  • Àngels García-Cazorla
    Affiliations
    Genetics and Molecular Medicine Service, Hospital Sant Joan de Déu and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain

    Department of Neurology, Neurometabolic Unit, Hospital Sant Joan de Déu and Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona, Spain
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  • Xavier Altafaj
    Affiliations
    Bellvitge Biomedical Research Institute–Unit of Neuropharmacology and Pain Group, University of Barcelona, Barcelona, Spain
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      This paper is only available as a PDF. To read, Please Download here.
      This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).
      This article has been retracted at the request of Editor John H. Krystal, M.D.
      Throughout this article, the authors report their molecular characterization of a GRIN2B mutation and the subsequent beneficial effects of using a D-serine dietary supplement as a treatment for a patient with Rett-like severe encephalopathy. However, it has come to light that the molecular work was conducted using D-serine, but the dietary supplement prescribed to the patient was actually L-serine. The authors notified the Journal upon this discovery, which was the result of a communication error, which was the result of a communication error, where D-serine was substituted with L-serine without the knowledge of the investigators. This led to the inadvertent misrepresentation in the article of the substance actually used in the clinical portion of this study.
      This fact not only significantly impacts the text of the entire article, but also requires consideration and discussion of the implications of the mismatch in addition to the completion of further studies to assess other potential contributing factors. Thus, it was determined that the only course of action was retraction. The authors are revising the paper, which the Journal will re-review and consider further for publication.

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      • Retraction
        Biological PsychiatryVol. 83Issue 8
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          Retraction notice to: “Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement” by David Soto, Mireia Olivella, Cristina Grau, Judith Armstrong, Clara Alcon, Xavier Gasull, Macarena Gómez de Salazar, Esther Gratacòs-Batlle, David Ramos-Vicente, Víctor Fernández-Dueñas, Francisco Ciruela, Àlex Bayés, Carlos Sindreu, Anna López-Sala, Àngels García-Cazorla, and Xavier Altafaj. Biological Psychiatry 2018; 83:160–172.
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