Evidence accumulated over the past decade suggests microRNAs (miRNAs) as novel targets
for the action of psychiatric drugs. These small regulatory noncoding RNAs contribute
to fine-tuning regulation of gene expression by messenger RNA destabilization and/or
translational repression; their abundance in the nervous system, their temporally
and spatially regulated expression, and their ability to respond in an activity-dependent
manner was suggested to make them ideal candidates for regulating complex neuronal
processes, including plasticity and memory formation (
1
). In this issue of Biological Psychiatry, Murphy et al. (
2
) report a novel potential miRNA-based “micro-switch” of a site- and task-specific
learning mechanism—namely the pivotal role miR-144-3p expression in the basolateral
amygdala (BLA) has in mechanisms of extinguishing conditioned fear.To read this article in full you will need to make a payment
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References
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- MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice.Biol Psychiatry. 2017; 81: 979-989
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Article info
Publication history
Accepted:
March 27,
2017
Received:
March 14,
2017
Identification
Copyright
© Society of Biological Psychiatry, 2017.
ScienceDirect
Access this article on ScienceDirectLinked Article
- MicroRNA-Mediated Rescue of Fear Extinction Memory by miR-144-3p in Extinction-Impaired MiceBiological PsychiatryVol. 81Issue 12Open Access
