Advertisement

Toward Micro-Switching Exposure Therapy: Potential Relevance for Posttraumatic Stress Disorder

  • Michael M. Tsoory
    Correspondence
    Address correspondence to Michael Tsoory, Ph.D., Weizmann Institute of Science, Department of Veterinary Resources, 234 Herzl Street, PO Box 26, Rehovot 7610001, Israel.
    Affiliations
    Behavioral and Physiological Phenotyping Unit, Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel
    Search for articles by this author
      Evidence accumulated over the past decade suggests microRNAs (miRNAs) as novel targets for the action of psychiatric drugs. These small regulatory noncoding RNAs contribute to fine-tuning regulation of gene expression by messenger RNA destabilization and/or translational repression; their abundance in the nervous system, their temporally and spatially regulated expression, and their ability to respond in an activity-dependent manner was suggested to make them ideal candidates for regulating complex neuronal processes, including plasticity and memory formation (
      • Issler O.
      • Chen A.
      Determining the role of microRNAs in psychiatric disorders.
      ). In this issue of Biological Psychiatry, Murphy et al. (
      • Murphy C.P.
      • Li X.
      • Maurer V.
      • Oberhauser M.
      • Gstir R.
      • Wearick-Silva L.E.
      • et al.
      MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice.
      ) report a novel potential miRNA-based “micro-switch” of a site- and task-specific learning mechanism—namely the pivotal role miR-144-3p expression in the basolateral amygdala (BLA) has in mechanisms of extinguishing conditioned fear.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Issler O.
        • Chen A.
        Determining the role of microRNAs in psychiatric disorders.
        Nat Rev Neurosci. 2015; 16: 201-212
        • Murphy C.P.
        • Li X.
        • Maurer V.
        • Oberhauser M.
        • Gstir R.
        • Wearick-Silva L.E.
        • et al.
        MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice.
        Biol Psychiatry. 2017; 81: 979-989
        • American Psychiatry Association
        Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Press, Washington, DC2013
        • Maren S.
        • Holmes A.
        Stress and fear extinction.
        Neuropsychopharmacology. 2016; 41: 58-79
        • Milad M.R.
        • Quirk G.J.
        Fear extinction as a model for translational neuroscience: Ten years of progress.
        Annu Rev Psychol. 2012; 63: 129-151
        • Bowers M.E.
        • Ressler K.J.
        An overview of translationally informed treatments for posttraumatic stress disorder: Animal models of Pavlovian fear conditioning to human clinical trials.
        Biol Psychiatry. 2015; 78: E15-E27
        • Risbrough V.B.
        • Glenn D.E.
        • Baker D.G.
        On the road to translation for PTSD treatment: Theoretical and practical considerations of the use of human models of conditioned fear for drug development.
        Curr Top Behav Neurosci. 2016; 28: 173-196
        • Giridharan V.V.
        • Thandavarayan R.A.
        • Fries G.R.
        • Walss-Bass C.
        • Barichello T.
        • Justice N.J.
        • et al.
        Newer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: Focus on post-traumatic stress disorder.
        Transl Psychiatry. 2016; 6: e954
        • Zhou J.
        • Nagarkatti P.
        • Zhong Y.
        • Ginsberg J.P.
        • Singh N.P.
        • Zhang J.
        • et al.
        Dysregulation in microRNA expression is associated with alterations in immune functions in combat veterans with post-traumatic stress disorder.
        PLoS One. 2014; 9: e94075
        • Wingo A.P.
        • Almli L.M.
        • Stevens J.S.
        • Klengel T.
        • Uddin M.
        • Li Y.
        • et al.
        DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression.
        Nat Commun. 2015; 6: 10106

      Linked Article