Evidence accumulated over the past decade suggests microRNAs (miRNAs) as novel targets for the action of psychiatric drugs. These small regulatory noncoding RNAs contribute to fine-tuning regulation of gene expression by messenger RNA destabilization and/or translational repression; their abundance in the nervous system, their temporally and spatially regulated expression, and their ability to respond in an activity-dependent manner was suggested to make them ideal candidates for regulating complex neuronal processes, including plasticity and memory formation (
1). In this issue of Biological Psychiatry, Murphy et al. (
- Issler O.
- Chen A.
Determining the role of microRNAs in psychiatric disorders.
Nat Rev Neurosci. 2015; 16: 201-212
2) report a novel potential miRNA-based “micro-switch” of a site- and task-specific learning mechanism—namely the pivotal role miR-144-3p expression in the basolateral amygdala (BLA) has in mechanisms of extinguishing conditioned fear.
- Murphy C.P.
- Li X.
- Maurer V.
- Oberhauser M.
- Gstir R.
- Wearick-Silva L.E.
- et al.
MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice.
Biol Psychiatry. 2017; 81: 979-989
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- Determining the role of microRNAs in psychiatric disorders.Nat Rev Neurosci. 2015; 16: 201-212
- MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice.Biol Psychiatry. 2017; 81: 979-989
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Accepted: March 27, 2017
Received: March 14, 2017
© Society of Biological Psychiatry, 2017.
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- MicroRNA-Mediated Rescue of Fear Extinction Memory by miR-144-3p in Extinction-Impaired MiceBiological PsychiatryVol. 81Issue 12Open Access