Advertisement

Solving the Eating Disorders Puzzle Piece by Piece

  • Cynthia M. Bulik
    Correspondence
    Address correspondence to Cynthia Bulik, Ph.D., CB #7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
    Affiliations
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Search for articles by this author
  • Gerome Breen
    Affiliations
    King’s College London, London, United Kingdom
    Search for articles by this author
      Albeit slowly, we are beginning to piece together the complex biological puzzle of anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). The article by Lutter et al. (
      • Lutter M.
      • Kahn M.Z.
      • Satio K.
      • Davis K.C.
      • Kidder I.J.
      • McDaniel L.
      • et al.
      The eating-disorder associated HDAC4A778T mutation alters feeding behaviors in female mice.
      ) in this issue of Biological Psychiatry brings us one step closer to understanding these illnesses.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Lutter M.
        • Kahn M.Z.
        • Satio K.
        • Davis K.C.
        • Kidder I.J.
        • McDaniel L.
        • et al.
        The eating-disorder associated HDAC4A778T mutation alters feeding behaviors in female mice.
        Biol Psychiatry. 2017; 81: 770-777
        • Yilmaz Z.
        • Hardaway A.
        • Bulik C.
        Genetics and epigenetics of eating disorders.
        Adv Genom Genet. 2015; 5: 131-150
      1. Duncan L, Yilmaz Z, Walters R, Goldstein J, Anttila V, Bulik-Sullivan B, Eating Disorders Working Group of the Psychiatric Genomics Consortium (in press): Genome-wide association study reveals first locus for anorexia nervosa and metabolic correlations. Am J Psychiatry.

        • Cui H.
        • Moore J.
        • Ashimi S.S.
        • Mason B.L.
        • Drawbridge J.N.
        • Han S.
        • et al.
        Eating disorder predisposition is associated with ESRRA and HDAC4 mutations.
        J Clin Invest. 2013; 123: 4706-4713
        • Schebendach J.E.
        • Klein D.A.
        • Mayer L.E.
        • Devlin M.J.
        • Attia E.
        • Walsh B.T.
        Assessment of fat taste in individuals with and without anorexia nervosa.
        Int J Eat Disord. 2014; 47: 215-218
        • Cederlöf M.
        • Thornton L.
        • Lichtenstein P.
        • Larsson H.
        • Boman M.
        • Rück C.
        • et al.
        Etiological overlap between obsessive-compulsive disorder and anorexia nervosa: A longitudinal cohort, family and twin study.
        World Psychiatry. 2015; 14: 333-338
        • Anttila V.
        • Bulik-Sullivan B.
        • Finucane H.
        • Anttila V.
        • Bulik-Sullivan B.
        • Finucane H.K.
        • et al.
        Analysis of shared heritability in common disorders of the brain [published online ahead of print Apr 16].
        bioRxiv. 2016; (http://biorxiv.org/content/early/2016/04/16/048991)
        • Gümmer R.
        • Giel K.E.
        • Schag K.
        • Resmark G.
        • Junne F.P.
        • Becker S.
        • et al.
        High levels of physical activity in anorexia nervosa: A systematic review.
        Euro Eat Disord Rev. 2015; 23: 333-344
        • Tozzi F.
        • Thornton L.
        • Klump K.
        • Bulik C.
        • Fichter M.
        • Halmi K.
        • et al.
        Symptom fluctuation in eating disorders: Correlates of diagnostic crossover.
        Am J Psychiatry. 2005; 162: 732-740
        • Lindfors C.
        • Nilsson I.A.
        • Garcia-Roves P.M.
        • Zuberi A.R.
        • Karimi M.
        • Donahue L.R.
        • et al.
        Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.
        Proc Natl Acad Sci U S A. 2011; 108: 18108-18113

      Linked Article