Recent findings from clinical epidemiology and developmental neurobiology have led
to the hypothesis that altered signalling of immune molecules in the brain may underlie
altered brain connectivity in psychosis. These ideas have received support from studies
of peripheral cytokines, PET data, and postmortem tissue, where findings have suggested
the presence of neuroinflammation in individuals with schizophrenia and severe mood
disorders. New developments in diffusion weighted imaging have suggested indexes of
free water, a putative marker of neuroinflammation, are elevated in patients with
psychosis. In the present study, we sought to confirm the presence of increased brain
free water in first episode psychosis (FEP) and to determine if and how this may change
over the first year of the illness.
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© 2017 Published by Elsevier Inc.
