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630. Free Water Alterations in the First Episode Psychosis: A 12-Month Longitudinal Study

      Recent findings from clinical epidemiology and developmental neurobiology have led to the hypothesis that altered signalling of immune molecules in the brain may underlie altered brain connectivity in psychosis. These ideas have received support from studies of peripheral cytokines, PET data, and postmortem tissue, where findings have suggested the presence of neuroinflammation in individuals with schizophrenia and severe mood disorders. New developments in diffusion weighted imaging have suggested indexes of free water, a putative marker of neuroinflammation, are elevated in patients with psychosis. In the present study, we sought to confirm the presence of increased brain free water in first episode psychosis (FEP) and to determine if and how this may change over the first year of the illness.
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