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400. Dysfunctional Emotion Discrimination in Schizophrenia is Associated with HSV-1 Infection and Improves with Antiviral Treatment

      Herpes simplex virus, type 1 (HSV-1) produces intermittent lytic, productive infection in many organs, alongside lifelong, latent infection in neurons. HSV-1 infected individuals have greater cognitive dysfunction than uninfected individuals, particularly persons with schizophrenia – even without encephalitis. We investigated whether HSV-1 related cognitive dysfunction is progressive or remediable.
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