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290. Altered Behavior, Sleep, and Epileptiform Activity in a Perinatal Multiple Hit Immune Activation Mouse Model of Autism Spectrum Disorder (ASD)

      Accumulating evidence supports a role for immune system function in autism spectrum disorder (ASD). Previous research shows that immune activation during critical developmental periods can trigger a phenotype that reproduces core features of ASD, including altered social interaction and communication. We recently developed a “multiple hit” immune model, whereby mice are exposed to repeated perinatal immune activation and then evaluated in tests representing behavioral domains dysregulated in ASD.
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