A hallmark of alcohol addiction is continued alcohol seeking despite adverse consequences.
Animal models have identified the medial prefrontal cortex and insula as key regions
for compulsive alcohol seeking (Seif et al., 2013). Despite the importance of compulsivity
in addiction, there have been few human studies investigating this phenomenon. Here,
we translate a preclinical paradigm to investigate the neural substrates of compulsive
alcohol seeking in human participants.
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© 2017 Published by Elsevier Inc.
