The dopamine hypothesis of gambling addiction is pervasive. Moreover, pathological
gamblers respond abnormally to dopaminergic drugs. However there is little to no direct
evidence for a categorical difference between pathological gamblers and controls in
terms of dopamine transmission at baseline. Multiple attempts to provide evidence
for the hypothesis that pathological gambling (PG), as in the case of drug addiction,
is accompanied by low dopamine D2-family receptor availability relative to controls,
have failed. Here we provide direct evidence for the dopamine hypothesis of PG by
focusing on a different aspect of dopamine transmission: synthesis capacity.
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© 2017 Published by Elsevier Inc.
