195. Increased Dopamine Synthesis Capacity in Gambling Addiction Predicts Drug-Induced Enhances in Reward Learning

      The dopamine hypothesis of gambling addiction is pervasive. Moreover, pathological gamblers respond abnormally to dopaminergic drugs. However there is little to no direct evidence for a categorical difference between pathological gamblers and controls in terms of dopamine transmission at baseline. Multiple attempts to provide evidence for the hypothesis that pathological gambling (PG), as in the case of drug addiction, is accompanied by low dopamine D2-family receptor availability relative to controls, have failed. Here we provide direct evidence for the dopamine hypothesis of PG by focusing on a different aspect of dopamine transmission: synthesis capacity.
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